Issue 96, 2024
From the journal:

Chemical Communications

Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules†

Toya Tabei,a   Kyoko Nakagawa-Goto ORCID logo ab  and  Yohei Saito ORCID logo *ac  

* Corresponding authors

a School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
E-mail: saito-y@staff.kanazawa-u.ac.jp

b Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, USA

c Advanced Preventive Medical Sciences Research Center, Kanazawa University, Takara-machi, Kanazawa, Ishikawa 920-8640, Japan

Abstract

We successfully found that boroxazolidone can dissociate under aqueous conditions, which were applicable to a solution containing proteins. The immobilization of a newly synthesized diarylborinic acid on beads enabled the capture and release of target proteins of bioactive compounds through boroxazolidone formation and dissociation.

Graphical abstract: Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules

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Article information

DOI
https://doi.org/10.1039/D4CC05370B
Article type
Communication
Submitted
15 Oct 2024
Accepted
08 Nov 2024
First published
08 Nov 2024

Chem. Commun., 2024,60, 14252-14255

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Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules

T. Tabei, K. Nakagawa-Goto and Y. Saito, Chem. Commun., 2024, 60, 14252 DOI: 10.1039/D4CC05370B

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