Carbon–carbon bond formation using aromatics from biomass

Abstract

The transition to a circular economy requires that we adapt currently used chemical processes to the structurally diverse and often highly oxygenated precursors that are accessible from biomass. In this review, we highlight different examples of carbon–carbon bond formation using aromatics derived from bio-based sources, reported during 2015–2024. Examples of sustainable biomass building blocks include heterocycles such as furfural and hydroxymethylfurfural, obtained from carbohydrates, as well as lignin-based aromatics such as vanillin and eugenol. These have subsequently been applied in a variety of different types of carbon–carbon bond formation, including more classical methods such as aldol condensation and Morita–Baylis–Hillman reactions, but also employing transition metal catalysis, electrochemistry or photochemistry to create new C–C bonds.