Issue 8, 2024

Peptide hydrogen-bonded organic frameworks

Abstract

Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.

Graphical abstract: Peptide hydrogen-bonded organic frameworks

Supplementary files

Article information

Article type
Tutorial Review
Submitted
19 Dec 2023
First published
07 Mar 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2024,53, 3640-3655

Peptide hydrogen-bonded organic frameworks

T. Vijayakanth, S. Dasgupta, P. Ganatra, S. Rencus-Lazar, A. V. Desai, S. Nandi, R. Jain, S. Bera, A. I. Nguyen, E. Gazit and R. Misra, Chem. Soc. Rev., 2024, 53, 3640 DOI: 10.1039/D3CS00648D

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