Issue 4, 2024

Electrophotoredox cerium-catalyzed decarboxylative radical cyclization cascade for the synthesis of alkylated benzimidazo-fused isoquinolinones

Abstract

We report here an electrophotoredox cerium-catalyzed ligand-to-metal-charge-transfer (LMCT) strategy to incorporate a broad range of primary, secondary and tertiary carboxylic acids into radical cyclization cascades under external oxidant-free conditions. This protocol provides a solution to address the challenges associated with alkylated benzimidazo-fused isoquinolinones synthesis. The high functional group compatibility was demonstrated by the tolerance of ester, carbonyl, amide, sulfonyl and hydroxyl groups.

Graphical abstract: Electrophotoredox cerium-catalyzed decarboxylative radical cyclization cascade for the synthesis of alkylated benzimidazo-fused isoquinolinones

Supplementary files

Article information

Article type
Paper
Submitted
05 Jan 2024
Accepted
23 Jan 2024
First published
24 Jan 2024

Catal. Sci. Technol., 2024,14, 1037-1042

Electrophotoredox cerium-catalyzed decarboxylative radical cyclization cascade for the synthesis of alkylated benzimidazo-fused isoquinolinones

M. Wang, D. Wang, K. Xu and C. Zeng, Catal. Sci. Technol., 2024, 14, 1037 DOI: 10.1039/D4CY00016A

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