Acrylamides from 1,2-dichloroethane via palladium-catalyzed carbonylation

Abstract

1,2-Dichloroethane, a widely produced chemical raw material, has attracted considerable attention due to its versatility in various applications. Herein, we report an efficient strategy for the synthesis of acrylamides via palladium-catalyzed carbonylation, using 1,2-dichloroethane and amines as starting materials. The catalytic system demonstrated remarkable tolerance towards a broad range of amines, producing the corresponding acrylamides in good to excellent yields. Remarkably, a variety of aromatic and alkyl amines were completely converted within 40 minutes, delivering the target products with an impressive 99% yield. Additionally, the strategy's versatility was confirmed by its successful application in the synthesis of functionalized acrylates. Importantly, the reaction was scaled up to 1 mmol scale with consistent yields, underscoring its potential for practical use in organic synthesis.