Molybdenum-maltolate as a molybdopterin mimic for bioinspired oxidation reaction

Swapnil S. Pawar; Rohit N. Ketkar; Pranav B. Gaware; Kaustubh U. Jagushte; Divyani Dhawne; Shreyada N. Save; Shilpy Sharma; Ganga Periyasamy; Niyamat Chimthanawala; Sadhana Sathaye; Shreerang V. Joshi; Nabanita Sadhukhan

doi:10.1039/D3DT04296K

Molybdenum-maltolate as a molybdopterin mimic for bioinspired oxidation reaction†

Swapnil S. Pawar,

^a Rohit N. Ketkar,

^a Pranav B. Gaware,^a Kaustubh U. Jagushte,

^a Divyani Dhawne,^a Shreyada N. Save,^b Shilpy Sharma,^b Ganga Periyasamy,

^c Niyamat Chimthanawala,^d Sadhana Sathaye,^d Shreerang V. Joshi

^d and Nabanita Sadhukhan

*^a

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* Corresponding authors

^a Department of Speciality Chemicals Technology, Institute of Chemical Technology, Mumbai, N.P. Marg, Matunga, Mumbai, Maharashtra – 400019, India
E-mail: nn.sadhukhan@ictmumbai.edu.in

^b Department of Biotechnology, Savitribai Phule Pune University, Ganeshkind Rd, Pune, Maharashtra – 411007, India

^c Department of Chemistry, Central College Campus, Bangalore University, Bangalore 560001, India

^d Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, N.P. Marg, Matunga, Mumbai, Maharashtra – 400019, India

Abstract

A novel cis-dioxomolybdenum(VI)-maltolate [MoO₂(Mal)₂] (1) is prepared as a stable molybdopterin model for the biomimetic catalysis of the oxidation of hypoxanthine in acetonitrile–water at room temperature. Compound 1 efficiently catalyzes the oxidation reaction of toluene, diphenylmethane, and styrene. Cyto- and oral-toxicity studies suggest its tremendous potential for application as a molybdenum supplement.

Dalton Transactions

Molybdenum-maltolate as a molybdopterin mimic for bioinspired oxidation reaction†

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