Issue 29, 2024

Tetracycline: structural characterization and antimicrobial properties of its water-soluble di-anionic bi-sodium salt

Abstract

The new water-soluble di-anionic bi-sodium salt of tetracycline (TC), an antibiotic in clinical use, with the formula {[TC]2โˆ’[Na+(MeOH)(H2O)] [Na+]ยท(H2O)}n (TCNa) was synthesized. The compound was characterized by m.p., attenuated total reflectance-Fourier transform infra-red (ATR-FTIR) spectroscopy, and ultraviolet (UV) and proton nuclear magnetic resonance (1H NMR) spectroscopy in the solid state and in solution. The molecular weight (MW) was determined by cryoscopy. The crystal structure of TCNa was also determined by X-ray crystallography. The antibacterial activity of TCNa was evaluated against the bacterial species Pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli), Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus) by means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibition zones (IZs). Moreover, the ability of the compound to eradicate biofilm formation was also evaluated. The results are compared with those obtained for the commercially available drug TCH2. The in vitro and in vivo toxicities of TCNa were tested against human corneal epithelial cells (HCECs) and Artemia salina.

Graphical abstract: Tetracycline: structural characterization and antimicrobial properties of its water-soluble di-anionic bi-sodium salt

Supplementary files

Article information

Article type
Paper
Submitted
10 May 2024
Accepted
23 May 2024
First published
03 Jun 2024
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2024,53, 12080-12089

Tetracycline: structural characterization and antimicrobial properties of its water-soluble di-anionic bi-sodium salt

A. S. Tsigara, C. N. Banti, A. Hatzidimitriou and S. K. Hadjikakou, Dalton Trans., 2024, 53, 12080 DOI: 10.1039/D4DT01384K

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