Issue 18, 2024

Construction of chlorogenic acid nanoparticles for effective alleviation of ulcerative colitis

Abstract

The onset and progression of ulcerative colitis (UC) are intricately linked to the worsening of intestinal inflammation, an imbalance in oxidative stress, and impairment of the intestinal mucosal barrier. Although chlorogenic acid (CA) shows potential in effectively alleviating the symptoms of UC, its clinical application is hindered by its poor bioavailability, stability, rapid metabolism, and quick excretion. This study utilized a one-step enzyme-catalyzed polymerization technique to create chlorogenic acid nanoparticles (CA NPs), aiming to improve the bioavailability and stability of CA. The CA NPs exhibited an optimal nanosize (106.65 ± 4.12 nm) and showed increased cellular uptake over time. Importantly, CA NPs significantly prolonged retention time in inflamed colonic tissues, enhancing accumulation and providing a targeted therapy for UC. Animal studies confirmed the substantial benefits of CA NPs, including reduced weight loss, lessened reduction in colon length, and a lowered disease activity index (DAI) score in DSS-induced UC mice. Moreover, CA NPs effectively reduced oxidative stress and levels of inflammatory factors in the colonic tissues of UC mice, thus mitigating tissue damage and restoring the integrity of the intestinal mucosal barrier. In conclusion, our research proposes a novel approach to increase the bioavailability and stability of CA, offering a promising avenue for its effective application in preventing UC.

Graphical abstract: Construction of chlorogenic acid nanoparticles for effective alleviation of ulcerative colitis

Supplementary files

Article information

Article type
Paper
Submitted
07 May 2024
Accepted
01 Aug 2024
First published
08 Aug 2024

Food Funct., 2024,15, 9085-9099

Construction of chlorogenic acid nanoparticles for effective alleviation of ulcerative colitis

S. Hu, R. Zhao, T. Chen, X. Chi, Y. Li, D. Wu, B. Zhu and J. Hu, Food Funct., 2024, 15, 9085 DOI: 10.1039/D4FO02122C

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