Issue 15, 2024

Visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes to construct densely functionalized α-CF3 tertiary alcohols

Abstract

A visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes is reported herein, which provides a series of α-trifluoromethyl-β-carboxyl tertiary alcohols under mild and environmentally friendly conditions in moderate to good yields. This protocol is enabled by SET between a photocatalyst and sodium formate to obtain CO2˙ without adding an additional HAT reagent. Broad substrate scope, excellent functional group compatibility, gram-scale synthesis and synthetic applications show the significant potential application of this protocol in the synthesis of a variety of compounds with densely functionalized α-CF3 tertiary alcohols.

Graphical abstract: Visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes to construct densely functionalized α-CF3 tertiary alcohols

Supplementary files

Article information

Article type
Communication
Submitted
06 Apr 2024
Accepted
28 Jun 2024
First published
04 Jul 2024

Green Chem., 2024,26, 8694-8700

Visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes to construct densely functionalized α-CF3 tertiary alcohols

M. Lu, N. Deng, S. Li, R. Tong, J. Xu and H. Xu, Green Chem., 2024, 26, 8694 DOI: 10.1039/D4GC01676A

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