Issue 18, 2024

Visible light-induced cobalt-catalyzed 1,3-diphosphination of alkenes

Abstract

1,3-Difunctionalization of alkenes, as a novel route for the modern development of alkene transformations, has drawn significant research attention in recent years. Herein, we disclose a novel cobalt-catalyzed radical 1,3-diphosphination of alkenes, which enables straightforward access to 1,3-diphosphine skeleton compounds under mild conditions without additional oxidants and photosensitizers. This transformation features excellent functional group tolerance, operational simplicity, and high atom economy, and is amenable for late-stage functionalization of complex molecule skeletons. Preliminary bioactivity studies reveal that these valuable 1,3-diphosphine products show potential antitumor activity.

Graphical abstract: Visible light-induced cobalt-catalyzed 1,3-diphosphination of alkenes

Supplementary files

Article information

Article type
Paper
Submitted
06 Jun 2024
Accepted
06 Aug 2024
First published
09 Aug 2024

Green Chem., 2024,26, 9749-9756

Visible light-induced cobalt-catalyzed 1,3-diphosphination of alkenes

W. Shan, Z. Wang, C. Gao, X. Li, W. Zhuang, R. Liu, C. Shi, H. Qin, X. Li and D. Shi, Green Chem., 2024, 26, 9749 DOI: 10.1039/D4GC02737J

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