Issue 21, 2024

Electroreductive deoxygenative carboxylation of alkyl oxalates with CO2

Abstract

An electroreductive deoxygenative carboxylation of alkyl oxalates with CO2 is demonstrated for the first time, which offers a general and scalable method for obtaining various carboxylic acids. This electrochemical method features a broad substrate scope and mild reaction conditions; various secondary benzyl alcohols and non-benzylic alcohols, primary benzyl alcohols and non-benzylic alcohols, and tertiary benzyl alcohols and non-benzylic alcohols can be converted into the corresponding carboxylic acids in good to excellent yields. Importantly, this electroreductive deoxygenative carboxylation reaction also offers a mild and straightforward route to access drug molecules, such as ibuprofen, (±) naproxen, fenoprofen, hexaprofen, and biprofen.

Graphical abstract: Electroreductive deoxygenative carboxylation of alkyl oxalates with CO2

Supplementary files

Article information

Article type
Communication
Submitted
15 Jul 2024
Accepted
01 Oct 2024
First published
02 Oct 2024

Green Chem., 2024,26, 10811-10817

Electroreductive deoxygenative carboxylation of alkyl oxalates with CO2

Y. Yuan, H. Jiang, Y. Zhang, Y. Tao, X. Liu and C. Huo, Green Chem., 2024, 26, 10811 DOI: 10.1039/D4GC03452J

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