Issue 4, 2024

Surface modification of bioactive glasses for successful incorporation with poly(lactic-co-glycolic acid) (PLGA)

Abstract

Bioactive glass (BG)–polymer composites are promising materials for bone grafting in bone tissue regeneration. BG provides rigidity and can initiate bone growth, whereas the polymer matrix provides flexibility and biocompatibility. However, due to the complex composition of BG, incorporation into the polymer matrix is difficult and often leads to unwanted porosity and low interface strength between both components. In this study, we investigate the surface treatment of commercially available micronized melt-derived BG with varying compositions (45S5 and 1393) to improve its incorporation into a poly(lactic-co-glycolic acid) (PLGA) matrix by improving surface roughness, surface charge and active sites on the BG. The surfaces of BG are modified by treatment in simulated body fluid (SBF) for 3 days prior to composite production. This leads to the formation of carbonated hydroxyapatite on the surface of both BG types, as demonstrated by XRD, FTIR, XPS and EDX. This also leads to a change in surface texture and an increase in specific surface area from initially 3 to 116 m2 g−1 and from 2 to 65 m2 g−1 for 45S5 and 1393, respectively. Subsequently, composite PLGA–BG microspheres are fabricated using a probe-ultrasonication assisted solid-in-oil-in-water emulsion method. Additionally, the surface interaction of bioactive glasses with PLGA is discussed in detail.

Graphical abstract: Surface modification of bioactive glasses for successful incorporation with poly(lactic-co-glycolic acid) (PLGA)

Supplementary files

Article information

Article type
Paper
Submitted
29 Dec 2023
Accepted
22 Mar 2024
First published
26 Mar 2024
This article is Open Access
Creative Commons BY-NC license

RSC Appl. Interfaces, 2024,1, 748-758

Surface modification of bioactive glasses for successful incorporation with poly(lactic-co-glycolic acid) (PLGA)

N. Jain, J. Schmidt, O. Görke, D. Karl, A. Gurlo and F. Schmidt, RSC Appl. Interfaces, 2024, 1, 748 DOI: 10.1039/D3LF00273J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements