Psilocybin analogues have been synthesized comprising a non-hydrolysable P–C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT2AR and 5-HT2BR and one compound showed a higher selectivity towards 5-HT2AR than psilocin.
M. Vandevelde, A. Simoens, B. Vandekerckhove and C. Stevens, RSC Med. Chem., 2024, 15, 998 DOI: 10.1039/D4MD00043A
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