Issue 4, 2024

A responsive cascade drug delivery scaffold adapted to the therapeutic time window for peripheral nerve injury repair

Abstract

Peripheral nerve injury (PNI) is a common clinical challenge, requiring timely and orderly initiation of synergistic anti-inflammatory and reparative therapy. Although the existing cascade drug delivery system can realize sequential drug release through regulation of the chemical structure of drug carriers, it is difficult to adjust the release kinetics of each drug based on the patient's condition. Therefore, there is an urgent need to develop a cascade drug delivery system that can dynamically adjust drug release and realize personalized treatment. Herein, we developed a responsive cascade drug delivery scaffold (RCDDS) which can adapt to the therapeutic time window, in which Vitamin B12 is used in early controllable release to suppress inflammation and nerve growth factor promotes regeneration by cascade loading. The RCDDS exhibited the ability to modulate the drug release kinetics by hierarchically opening polymer chains triggered by ultrasound, enabling real-time adjustment of the anti-inflammatory and neuroregenerative therapeutic time window depending on the patient's status. In the rat sciatic nerve injury model, the RCDDS group was able to achieve neural repair effects comparable to the autograft group in terms of tissue structure and motor function recovery. The development of the RCDDS provides a useful route toward an intelligent cascade drug delivery system for personalized therapy.

Graphical abstract: A responsive cascade drug delivery scaffold adapted to the therapeutic time window for peripheral nerve injury repair

Supplementary files

Article information

Article type
Communication
Submitted
20 Sep 2023
Accepted
29 Nov 2023
First published
30 Nov 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Horiz., 2024,11, 1032-1045

A responsive cascade drug delivery scaffold adapted to the therapeutic time window for peripheral nerve injury repair

Y. Shan, L. Xu, X. Cui, E. Wang, F. Jiang, J. Li, H. Ouyang, T. Yin, H. Feng, D. Luo, Y. Zhang and Z. Li, Mater. Horiz., 2024, 11, 1032 DOI: 10.1039/D3MH01511D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements