Issue 3, 2024

Development and application of mass spectrometric molecular networking for analyzing the ingredients of areca nut

Abstract

Areca nut (Areca catechu L.) is commonly consumed as a chewing food in the Asian region. However, the investigations into the components of areca nut are limited. In this study, we have developed an approach that combines mass spectrometry with feature-based molecular network to explore the chemical characteristics of the areca nut. In comparison to the conventional method, this technique demonstrates a superior capability in annotating unknown compounds present in areca nut. We annotated a total of 52 compounds, including one potential previously unreported alkaloid, one carbohydrate, and one phenol and confirmed the presence of 7 of them by comparing with commercial standards. The validated method was used to evaluate chemical features of areca nut at different growth stages, annotating 25 compounds as potential biomarkers for distinguishing areca nut growth stages. Therefore, this approach offers a rapid and accurate method for the component analysis of areca nut.

Graphical abstract: Development and application of mass spectrometric molecular networking for analyzing the ingredients of areca nut

Supplementary files

Article information

Article type
Research Article
Submitted
14 Nov 2023
Accepted
20 Dec 2023
First published
21 Dec 2023

Mol. Omics, 2024,20, 192-202

Development and application of mass spectrometric molecular networking for analyzing the ingredients of areca nut

J. Zhao, J. Shi, X. Chen, Y. Lei, T. Tian, S. Zhu, C. Tan, Y. Liu and Y. Xu, Mol. Omics, 2024, 20, 192 DOI: 10.1039/D3MO00232B

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