Issue 4, 2024

Al2O3 promoted mechanochemical nucleophilic aromatic substitution

Abstract

An auxiliary mediated solventless mechanochemical methodology for the nucleophilic aromatic substitution of aryl fluorides by nitrogen nucleophiles without the aid of any base has been developed. The excellent affinity of Al2O3 for hydrogen fluoride is the key for this process. Thanks to the use of Al2O3 as a milling auxiliary yields of up to 99% were achieved, and the easily processable crude derived from the milling jar allowed a simple and fast work-up procedure, making this method very attractive.

Graphical abstract: Al2O3 promoted mechanochemical nucleophilic aromatic substitution

Supplementary files

Article information

Article type
Paper
Submitted
21 Apr 2024
Accepted
08 May 2024
First published
09 May 2024
This article is Open Access
Creative Commons BY-NC license

RSC Mechanochem., 2024,1, 342-348

Al2O3 promoted mechanochemical nucleophilic aromatic substitution

L. Vaghi, E. Palomba and A. Papagni, RSC Mechanochem., 2024, 1, 342 DOI: 10.1039/D4MR00039K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements