Issue 10, 2024
From the journal:

New Journal of Chemistry

A heparan sulfate proteoglycan-mimicking AIE fluorescent probe for SARS-CoV-2 detection†

Fang Liu,a   Yue Huang,a   Yutong Li,a   Yongcheng Chen,a   Qiao Jin ORCID logo *a  and  Jian Ji ORCID logo *ab  

* Corresponding authors

a MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
E-mail: jinqiao@zju.edu.cn, jijian@zju.edu.cn

b Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, China

Abstract

A heparan sulfate proteoglycan (HSPG)-mimicking fluorescent probe, tetrasulfonated tetraphenylethene (TPES), with aggregation-induced emission (AIE) characteristics is designed for fast SARS-CoV-2 detection. TPES can adhere to SARS-CoV-2 by the strong interaction between the sulfonic acid groups of TPES and the spike proteins of SARS-CoV-2, leading to a significant fluorescence enhancement.

Graphical abstract: A heparan sulfate proteoglycan-mimicking AIE fluorescent probe for SARS-CoV-2 detection

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Article information

DOI
https://doi.org/10.1039/D3NJ04949C
Article type
Communication
Submitted
26 Oct 2023
Accepted
08 Feb 2024
First published
09 Feb 2024

New J. Chem., 2024,48, 4208-4212

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A heparan sulfate proteoglycan-mimicking AIE fluorescent probe for SARS-CoV-2 detection

F. Liu, Y. Huang, Y. Li, Y. Chen, Q. Jin and J. Ji, New J. Chem., 2024, 48, 4208 DOI: 10.1039/D3NJ04949C

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