Selective and sensitive non-enzymatic detection of glucose by Cu(ii)–Ni(ii)/SBA-15

Abstract

Monitoring blood glucose levels in diabetic patients is vital, pressing the need for sensitive and affordable glucose sensors. Electrochemical sensing, gaining prominence due to drawbacks of enzymatic and optical methods, has been a major research focus. Here, we explore mesoporous Santa Barbara Amorphous-15 (SBA-15) supported bimetallic copper nickel oxide for electrochemical glucose estimation. Rigorous characterisation via XRD, BET, and XPS confirmed metal oxide integration into the SBA-15, and the retention of the framework was validated by XRD, SEM, and TEM analyses. Cyclic voltammetry (CV) studies revealed sensor versatility across the 10 to 900 μM range with a commendable lower detection limit of 1.19 μM. Furthermore, the optimized 30Cu–20Ni/SBA-15/Triton/GCE sensor exhibited exceptional stability and negligible interference from common interfering species such as sucrose, fructose, uric acid, and ascorbic acid. In addition, the practical utility was tested by employing artificial blood serum and urine samples. The sensor's outstanding attributes, including cost-effectiveness and clinical suitability, present promising advancements in electrochemical glucose detection, opening new avenues in electrochemical sensing.