Unexpected 20-membered macrocycles obtained by the condensation of α,α-dihalo-β-oxoaldehydes with diaminofurazan†
Abstract
Herein, we have isolated new 20-membered macrocycles by the simple condensation of α,α-dihalo-β-oxoaldehydes with diaminofurazan in acetonitrile. The interior and exterior sites of these macrocycles comprise hydrogen and halogen bond donor sites, respectively. Depending on the electron donating or accepting character of the substituents at the exterior sites of macrocyclic scaffolds, the average cavity diameters range from 8.15 to 8.47 Å.