Issue 32, 2024

tert-Butyl nitrite as a privileged reagent for a C–H bond (sub)nitration reaction in organic synthesis

Abstract

Nitro compounds are important intermediates in medicine, agrochemicals, dyes and polymers. In recent years, the use of tert-butyl nitrite (t-BuONO) has attracted great attention and research involving it has made promising progress. Currently, there is no review that specifically discusses the use of t-BuONO for the synthesis of nitro compounds via a C–H bond radical strategy. Therefore, this review aims to focus on the recent progress in the use of t-BuONO as a nitration reagent according to the type of reaction substrate, especially to focus on the discussion of the reaction mechanism in representative cascade reactions to provide insights for the development prospects of tert-butyl nitrite.

Graphical abstract: tert-Butyl nitrite as a privileged reagent for a C–H bond (sub)nitration reaction in organic synthesis

Article information

Article type
Perspective
Submitted
19 Apr 2024
Accepted
20 Jul 2024
First published
24 Jul 2024

New J. Chem., 2024,48, 14128-14139

tert-Butyl nitrite as a privileged reagent for a C–H bond (sub)nitration reaction in organic synthesis

J. Ma, P. Chen, J. Zeng, P. Guo and H. Cheng, New J. Chem., 2024, 48, 14128 DOI: 10.1039/D4NJ01802H

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