Colletotrikalactones A and B, unusual tricyclic polyketides from mangrove associated fungus Colletotrichum sp. J065

Abstract

Two novel polyketides, called colletotrikalactones A and B (1 and 2), together with eleven known compounds (3–13) were isolated from the culture broth of the mangrove associated fungus Colletotrichum sp. J065. Compounds 1 and 2 featured a rare 5/6/10-fused tricyclic scaffold. The new structures were elucidated through comprehensive spectroscopic analyses and chemical transformation.