Issue 41, 2024

Optical dark-field spectroscopy of single plasmonic nanoparticles for molecular biosciences

Abstract

An ideal sensor capable of quantifying analytes in minuscule sample volumes represents a significant technological advancement. Plasmonic nanoparticles integrated with optical dark-field spectroscopy have reached this capability, demonstrating versatility and expanding applicability across in vitro and in vivo subjects. This review underscores the applicability of optical dark-field spectroscopy with single plasmonic nanoparticles to elucidate a wide range of biomolecular characteristics, including binding constants, molecular dynamics, distances, and forces, as well as recording cell communication signals. Perspectives highlight the potential for the development of implantable nanosensors for metabolite detection in animal models, illustrating the technique's efficacy without the need for labeling molecules. In summary, this review aims to consolidate knowledge of this adaptable and robust technique for decoding molecular biological phenomena within the nano- and bio-scientific community.

Graphical abstract: Optical dark-field spectroscopy of single plasmonic nanoparticles for molecular biosciences

Article information

Article type
Review Article
Submitted
23 Jul 2024
Accepted
26 Sep 2024
First published
26 Sep 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2024,16, 19192-19206

Optical dark-field spectroscopy of single plasmonic nanoparticles for molecular biosciences

L. Labrador-Páez, A. Casasnovas-Melián, E. Junquera, A. Guerrero-Martínez and R. Ahijado-Guzmán, Nanoscale, 2024, 16, 19192 DOI: 10.1039/D4NR03055A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements