Issue 1, 2024

A chloride-responsive molecular switch: driving ion transport and empowering antibacterial properties

Abstract

A molecular switch was developed to recognize and transport Cl across lipid bilayers. The XRD-crystal structure and NOESY NMR spectra of a potent 4-aminoquinazoline analogue confirmed Cl-induced conformation changes. Systematic biophysical studies revealed that the quinazoline moiety forms cooperative interactions of H+ and Cl ions with the thiourea moiety, resulting in the transport of H+/Cl across the membranes. A pH-dependent analysis revealed that the transport of Cl by the potent compound increased in an acidic environment. The potent compound could also transport H+/Cl across Gram-positive bacteria, leading to antibacterial activities.

Graphical abstract: A chloride-responsive molecular switch: driving ion transport and empowering antibacterial properties

Supplementary files

Article information

Article type
Paper
Submitted
08 Nov 2023
Accepted
21 Nov 2023
First published
24 Nov 2023

Org. Biomol. Chem., 2024,22, 114-119

A chloride-responsive molecular switch: driving ion transport and empowering antibacterial properties

S. Das, R. Karn, M. Kumar, S. Srimayee and D. Manna, Org. Biomol. Chem., 2024, 22, 114 DOI: 10.1039/D3OB01826A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements