Issue 12, 2024
From the journal:

Organic & Biomolecular Chemistry

Nickel-catalyzed acylation of vinylpyridine with alkylzincs under 1 atm CO†

Wenyi Huang,a   Chenglong Wang,a   Yetong Zhang,a   Jingping Qu ORCID logo a  and  Yifeng Chen ORCID logo *ab  

* Corresponding authors

a Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering East China University of Science and Technology, 130 Meilong Road, Shanghai, China
E-mail: yifengchen@ecust.edu.cn

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P R China

Abstract

A nickel-catalyzed acylation of vinylpyridines with CO at atmospheric pressure is reported, allowing for an expedient approach to synthesize β-acyl pyridine derivatives with high regio- and chemoselectivity. The electron-withdrawing property of pyridine plays pivotal roles in activating the alkenyl group, thereby facilitating this carbonylative process. In addition to vinylpyridines, other alkenylheterocycles such as thiazole and quinoline were also suitable for this method.

Graphical abstract: Nickel-catalyzed acylation of vinylpyridine with alkylzincs under 1 atm CO

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Article information

DOI
https://doi.org/10.1039/D4OB00165F
Article type
Communication
Submitted
31 Jan 2024
Accepted
25 Feb 2024
First published
26 Feb 2024

Org. Biomol. Chem., 2024,22, 2380-2383

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Nickel-catalyzed acylation of vinylpyridine with alkylzincs under 1 atm CO

W. Huang, C. Wang, Y. Zhang, J. Qu and Y. Chen, Org. Biomol. Chem., 2024, 22, 2380 DOI: 10.1039/D4OB00165F

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