Issue 21, 2024

Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis

Abstract

Protamine-mediated micellar aggregates, featuring an AIE-based fluorescent sensor, facilitate efficient detection of trypsin activity. This method enables the detection of trypsin at exceptionally low concentrations (0.01–0.1 μg mL−1) in urine, demonstrating its potential for early clinical diagnosis of trypsin-related pancreatic diseases.

Graphical abstract: Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis

Supplementary files

Article information

Article type
Communication
Submitted
24 Mar 2024
Accepted
29 Apr 2024
First published
02 May 2024

Org. Biomol. Chem., 2024,22, 4243-4248

Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis

H. Song, H. Choi, Y. Kim and S. H. Lee, Org. Biomol. Chem., 2024, 22, 4243 DOI: 10.1039/D4OB00478G

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