In this communication, a practical method for using cheap and easily available silylene chlorides for diol protection is presented. The method is based on activation of the reagents using Finkelstein-like conditions. Silylene acetals of carbohydrates are synthesized, and it is furthermore shown how these can be regioselectively opened using Grignard reagents.
M. L. Zimmermann, D. M. Feldballe and C. M. Pedersen, Org. Biomol. Chem., 2024, 22, 5977 DOI: 10.1039/D4OB00721B
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