A protein modification strategy was developed based on a thiol–yne click reaction using an electron-deficient yne reagent. This approach demonstrated exceptional selectivity towards thiols and exhibited rapid kinetics, resulting in conjugates with superior acid stability. The conjugation of IgG with an indole-derived fluorophore was achieved for the imaging of PD-L1 in cancer cells.
Z. Chen, W. Chen, F. Wang, J. Jiang and W. Dong, Org. Biomol. Chem., 2024, 22, 7311 DOI: 10.1039/D4OB01037J
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