Copper-promoted ortho-directed C–H amination of 2-arylpyridines with NH-heterocycles

Abstract

Copper-mediated C–N coupling of azaheterocycles with aryl C–H bonds has been realized for the synthesis of N-(hetero)arylated heteroarenes. This method is characterized by high regioselectivity, atom economy and a wide substrate scope of 2-arylazines and azaheterocycles. The corresponding C–N coupling products were shown to undergo further transformation to synthesize more complex molecules.