Issue 35, 2024

A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides

Abstract

A practical and efficient method for the C-3 site selective alkenylation of indoles was developed for constructing novel indole-functionalized vinyl sulfonyl fluorides and indolyl allylic sulfonyl fluorides. The reaction is accomplished with exclusive regio- and stereoselectivity without using transition metal catalysts, providing novel products of great potential value in medicinal chemistry, chemical biology, and drug discovery.

Graphical abstract: A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2024
Accepted
12 Aug 2024
First published
16 Aug 2024

Org. Biomol. Chem., 2024,22, 7117-7120

A portal to highly valuable indole-functionalized vinyl sulfonyl fluorides and allylic sulfonyl fluorides

W. Huang, E. Fayad, O. A. Abu Ali and H. Qin, Org. Biomol. Chem., 2024, 22, 7117 DOI: 10.1039/D4OB01213E

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