Issue 16, 2024

A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy

Abstract

In conventional tumor therapy, most nanomaterials accumulate non-specifically in target areas through enhanced permeability and retention effects, leading to poor therapeutic outcomes. In this paper, a multifunctional composite nanotherapeutic platform COF/ICG@PDA-Apt-A was prepared for targeted and combined photothermal–photodynamic therapy of tumors. The successful introduction of indocyanine green and polydopamine greatly enhanced the photothermal (photothermal conversion efficiency of up to 43.3%) and photodynamic performance of the nanotherapeutic platform. Under the active targeting action of the aptamer, the nanotherapeutic platform showed satisfactory anti-tumor ability through combination therapy. This work may contribute to the development of new active targeted delivery platforms, improving delivery efficiency and therapeutic effectiveness.

Graphical abstract: A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy

Supplementary files

Article information

Article type
Research Article
Submitted
22 Mar 2024
Accepted
04 Jun 2024
First published
05 Jun 2024

Mater. Chem. Front., 2024,8, 2736-2744

A covalent organic framework-based nanoplatform with enhanced photothermal and photodynamic performance for targeted tumor therapy

C. Wang, Z. Xin, Z. Bai, J. Mao, Y. Li, Z. Jia, K. Wang, L. Zhao, Y. Bai and F. Feng, Mater. Chem. Front., 2024, 8, 2736 DOI: 10.1039/D4QM00236A

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