Issue 1, 2024

A novel three-component coupling reaction of aryne, C[double bond, length as m-dash]N derivatives, and acrylonitrile

Abstract

A literature-unprecedented three-component aryne coupling reaction with pyrroline, imine, dihydroisoquinoline, imidazoline or oxazoline as a nucleophile, and acrylonitrile as a third component, acting as both a proton donor and a nucleophile, has been developed. With imidazoline or oxazoline as the substrate, the initially formed three-component reaction product could react further to provide tetrahydro-1,4-diazepine or tetrahydro-1,4-oxazepine, respectively.

Graphical abstract: A novel three-component coupling reaction of aryne, C [[double bond, length as m-dash]] N derivatives, and acrylonitrile

Supplementary files

Article information

Article type
Research Article
Submitted
08 Sep 2023
Accepted
11 Nov 2023
First published
13 Nov 2023

Org. Chem. Front., 2024,11, 89-93

A novel three-component coupling reaction of aryne, C[double bond, length as m-dash]N derivatives, and acrylonitrile

Y. Wu, W. Cai, L. Yu, J. Chang and C. Song, Org. Chem. Front., 2024, 11, 89 DOI: 10.1039/D3QO01454A

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