Issue 6, 2024

An electrochemical multicomponent cascade annulation and functionalization reaction to enable C(sp3)–H trifluoromethylation

Abstract

Herein, we describe a novel electrochemistry facilitated one-pot multicomponent cascade annulation and bi-functionalization reaction that enables the efficient synthesis of highly functionalized 3,4-dihydroquinazolinones from readily available starting materials, realizing indirect C(sp3)–H trifluoromethylation of aromatic ketones. This methodology achieves two goals in one simple reaction, the direct synthesis of quinazolinones and the concurrent introduction of functional groups. This transformation has good compatibility with common functional groups and the scale-up electrolysis can be easily performed.

Graphical abstract: An electrochemical multicomponent cascade annulation and functionalization reaction to enable C(sp3)–H trifluoromethylation

Supplementary files

Article information

Article type
Research Article
Submitted
16 Oct 2023
Accepted
20 Dec 2023
First published
22 Dec 2023

Org. Chem. Front., 2024,11, 1662-1667

An electrochemical multicomponent cascade annulation and functionalization reaction to enable C(sp3)–H trifluoromethylation

Y. Ding, H. Zhang, D. Lou, W. Huang, Y. Shi, H. Luo, C. Zhang and Y. Xie, Org. Chem. Front., 2024, 11, 1662 DOI: 10.1039/D3QO01684F

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