Issue 4, 2024
From the journal:

Organic Chemistry Frontiers

Electro-induced O–S bonding reaction targeting biological macromolecules†

Shuqiang Jiang,a   Longyu Xiao,a   Li Pan,b   Qiaoyu Huang,c   Fujin Huo,a   Meng Gao, ORCID logo a   Cuifen Lu, ORCID logo a   Pan Wu*b  and  Yue Weng ORCID logo *a  

* Corresponding authors

a Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecule, State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Chemistry and Chemical Engineering, Hubei University, Wuhan, P. R. China
E-mail: wengyue@hubu.edu.cn

b State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, P. R. China

c Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan, P. R. China

Abstract

This study endeavors to explore the utilization of aromatic sulfinates as bioconjugation handles, addressing the challenges associated with the modification of aromatic amino acid residues (Tyrosine) and paving the way for innovative approaches to biomolecule functionalization. Mechanistic investigations have indicated the potential involvement of a radical mechanism in the reaction.

Graphical abstract: Electro-induced O–S bonding reaction targeting biological macromolecules

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Article information

DOI
https://doi.org/10.1039/D3QO01794J
Article type
Research Article
Submitted
31 Oct 2023
Accepted
19 Dec 2023
First published
20 Dec 2023

Org. Chem. Front., 2024,11, 1090-1096

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Electro-induced O–S bonding reaction targeting biological macromolecules

S. Jiang, L. Xiao, L. Pan, Q. Huang, F. Huo, M. Gao, C. Lu, P. Wu and Y. Weng, Org. Chem. Front., 2024, 11, 1090 DOI: 10.1039/D3QO01794J

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