The synthesis of isoxazolines and dihydrooxazines by Pd-catalyzed oxyalkynylation alkenyl oximes with alkynyl bromides

Abstract

An efficient Pd-catalyzed oxyalkynylation of alkenyl oximes with alkynyl bromides has been demonstrated. This is a novel method for the synthesis of diverse isoxazolines and dihydrooxazines bearing a alkyne group by the simultaneous formation of C(sp³)–O and C(sp³)–C(sp) bonds in one pot. This new approach has a broad substrate scope and good functional group tolerance.