Site-selective C(sp3)–H functionalization of primary aliphatic amines
Abstract
C–H bond functionalization represents one of the most efficient and straightforward strategies for diversifying existing molecules. The most challenging task to achieve is the site-selective C(sp3)–H functionalization of primary aliphatic amines in modern organic synthesis, which has received much attention in recent years. On the one hand, the combining of photoredox catalysis (PC) and hydrogen atom transfer (HAT) for α-C(sp3)–H functionalization has been achieved via a free radical pathway. On the other hand, significant progress has also been made in native amine-directed γ- and δ-C(sp3)–H functionalization catalyzed by palladium catalysts. In this review, we systematically summarize the site-selective C(sp3)–H functionalization of primary aliphatic amines, as well as discuss the mechanisms.
- This article is part of the themed collections: 2024 Organic Chemistry Frontiers HOT articles and 2024 Organic Chemistry Frontiers Review-type Articles