Issue 14, 2024

para-Selective radical alkylation of pyridines with diacyl peroxides and peresters

Abstract

Herein, a practical method for the para-selective alkylation of various pyridines using the corresponding oxazino pyridine intermediates and cheap alkyl carboxylic acid-derived diacyl peroxides or peresters as alkyl radical precursors and internal oxidants is reported. The transformation proceeds in the absence of any transition metal catalyst, is easy to scale up and can be used in consecutive radical para,ortho-difunctionalization.

Graphical abstract: para-Selective radical alkylation of pyridines with diacyl peroxides and peresters

Supplementary files

Article information

Article type
Research Article
Submitted
09 May 2024
Accepted
29 May 2024
First published
29 May 2024

Org. Chem. Front., 2024,11, 3849-3854

para-Selective radical alkylation of pyridines with diacyl peroxides and peresters

Z. Wang, P. Xu and A. Studer, Org. Chem. Front., 2024, 11, 3849 DOI: 10.1039/D4QO00814F

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