Decatungstate-photocatalyzed radical addition of C(sp3)–H to azauracils

Abstract

This study presents a gentle and remarkably effective decatungstate ([W₁₀O₃₂]⁴⁻)-photocatalyzed method for the hydroalkylation of azauracils using a wide range of primary, secondary, and tertiary unreactive C–H bonds of alkanes as the alkylating reagents. Notable features of this approach include its mild reaction conditions, significant atom and step efficiency, a broad range of applicable substrates, and its ability to facilitate the post-synthesis customization of complex pharmaceutical compounds. Additionally, the reaction could be effectively scaled up to a gram scale using continuous-flow conditions.