Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells

Abstract

Choriocarcinoma can be cured by chemotherapy, but this causes resistance and severe side effects that bring about physical and psychological consequences for patients. Therefore, there is still an urgent need to find other alternative minimally invasive therapies to halt the progression of choriocarcinoma. Novel carbon-coated selenium nanoparticles (C–Se) were successfully synthesized for choriocarcinoma photothermal therapy. C–Se combined with near-infrared laser irradiation can inhibit the proliferation of human choriocarcinoma (JEG-3) cells and induce cell apoptosis. C–Se killed cells and produced ROS under near-infrared laser irradiation. Finally, the therapeutic mechanism of C–Se + laser was explored showing that C–Se + laser influenced numerous biological processes. Taken together, C–Se exhibited significant potential for choriocarcinoma photothermal therapy.