Issue 21, 2024, Issue in Progress

Mechanism insight into the high-efficiency catalytic killing of E. coli by metal–phenolic network as a nanozyme

Abstract

Glutathione (GSH) as an antioxidant greatly attenuates the reactive oxygen species (ROS) treatment strategy based on peroxidase-activity nanozymes. Therefore, nanozymes with multiple properties that generate ROS and further GSH-depletion functions would be of great benefit to improve antimicrobial efficacy. Herein, focusing on the green, safe and abundant functional prospects of metal–phenolic networks (MPNs) and the strong prospect of biomedical applications, we have synthesized copper tannic acid (CuTA) nanozymes with dual functional properties similar to peroxidase-like activity and GSH depletion. CuTA can catalyze the decomposition of H2O2 to hydroxyl radicals (˙OH). In addition, CuTA nanozymes can efficiently deplete available GSH, thus enhancing ROS-mediated antimicrobial therapy. The antibacterial results show that CuTA has an excellent antibacterial effect against E. coli.

Graphical abstract: Mechanism insight into the high-efficiency catalytic killing of E. coli by metal–phenolic network as a nanozyme

Supplementary files

Article information

Article type
Paper
Submitted
18 Jan 2024
Accepted
28 Apr 2024
First published
08 May 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 15106-15111

Mechanism insight into the high-efficiency catalytic killing of E. coli by metal–phenolic network as a nanozyme

W. Guo, C. Wu, G. Li, Y. Wang, S. He, J. Huang, X. Gao and X. Yue, RSC Adv., 2024, 14, 15106 DOI: 10.1039/D4RA00481G

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