Issue 35, 2024

Conformational studies of biaryl-bridged seven-membered lactones with a quaternary carbon center

Abstract

We show the synthesis and conformational studies of a series of 7,7-disubstituted-dibenzo[b,d]oxepin-6(7H)-ones that feature biaryl-bridged seven-membered lactones with a quaternary carbon center, in which the larger substituents prefer the axial positions. Further studies on the crystal structures and DFT calculations revealed that the high selectivity observed is attributed to the volume of substituents.

Graphical abstract: Conformational studies of biaryl-bridged seven-membered lactones with a quaternary carbon center

Supplementary files

Article information

Article type
Paper
Submitted
28 Jun 2024
Accepted
09 Aug 2024
First published
14 Aug 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 25663-25668

Conformational studies of biaryl-bridged seven-membered lactones with a quaternary carbon center

Y. Zhang, Y. Yu, X. Ma, X. Zhao, J. Huang and D. Zhao, RSC Adv., 2024, 14, 25663 DOI: 10.1039/D4RA04703F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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