Generation of reactive oxygen species (ROS) within the ER evokes stress leading to immunogenic cell death. A red light activated BODIPY dye capable of subcellular localization within the ER producing high quantum yields of ROS is reported. The ability of this dye to act as a photodynamic therapy (PDT) agent in breast cancer cells suggests promising organelle-targeted therapeutics.
S. Swavey, A. Quentel, M. Grzesiak, C. Hawkins and P. Vidi, RSC Adv., 2024, 14, 38796 DOI: 10.1039/D4RA05603E
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