Thermal/photochemical micro-flow probe system for direct C–H bond functionalization of biologically active molecules

Abstract

Over the past few decades, many solar radiation (heat + light)-based reactions have been developed to allow utilization of thermal/light energy to facilitate chemical reactions. However, fluctuating light intensity, clouds, night, and global location render such system less efficient (approximately 33%, being usable for only 8 h out of 24 h). Radiation-induced direct C–H activation with aqueous ammonia is rarely reported. Herein, we report an innovative approach that merges a solar tracker with the artificial-radiation-induced in situ generation of explosive diazo-compounds and is further extended to N–H insertion into biologically active molecules.