Comparative study of the antiproliferative activity of heterometallic carbene gold(I)–platinum(II) and gold(I)–palladium(II) complexes in cancer cell lines

Martin C. Dietl; Melina Maag; Sophia Ber; Frank Rominger; Matthias Rudolph; Isabella Caligiuri; Pacome K. Andele; Ibraheem A. I. Mkhalid; Flavio Rizzolio; Pablo A. Nogara; Laura Orian; Thomas Scattolin; A. Stephen K. Hashmi

doi:10.1039/D4SC04585H

Comparative study of the antiproliferative activity of heterometallic carbene gold(i)–platinum(ii) and gold(i)–palladium(ii) complexes in cancer cell lines†

Martin C. Dietl,

^a Melina Maag,

^a Sophia Ber,^a Frank Rominger,^a Matthias Rudolph,^a Isabella Caligiuri,^b Pacome K. Andele,

^bc Ibraheem A. I. Mkhalid,^d Flavio Rizzolio,

^be Pablo A. Nogara,

^f Laura Orian,

^g Thomas Scattolin

*^g and A. Stephen K. Hashmi

*^ad

Author affiliations

* Corresponding authors

^a Organisch-Chemisches Institut, Heidelberg University, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
E-mail: hashmi@hashmi.de

^b Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS via Franco Gallini 2, Aviano, Italy

^c Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari, Campus Scientifico Via Torino 155, 30174 Venezia-Mestre, Italy

^d Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia

^e Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari, Campus Scientifico Via Torino 155, 30174 Venezia-Mestre, Italy

^f Instituto Federal de Educação, Ciência e Tecnologia Sul-rio-grandense (IFSul), Av. Leonel de Moura Brizola, 2501, Bagé, RS, Brazil

^g Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via Marzolo 1, 35131 Padova, Italy
E-mail: thomas.scattolin@unipd.it

Abstract

The stepwise, one-pot synthesis of heterobimetallic carbene gold(I) platinum(II) complexes from readily available starting materials is presented. The protecting group free methodology is based on the graduated nucleophilicities of aliphatic and aromatic amines as linkers between both metal centers. This enables the selective, sequential installation of the metal fragments. In addition, the obtained complexes were tested as potential anticancer agents and directly compared to their gold(I) palladium(II) counterparts.

Chemical Science

Comparative study of the antiproliferative activity of heterometallic carbene gold(i)–platinum(ii) and gold(i)–palladium(ii) complexes in cancer cell lines†

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Comparative study of the antiproliferative activity of heterometallic carbene gold(I)–platinum(II) and gold(I)–palladium(II) complexes in cancer cell lines

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