Volume 3, 2024
From the journal:

Sensors & Diagnostics

Extracellular vesicle analysis in supramolecular 3D hydrogels: a proof-of-concept†

Greta Bergamaschi, ORCID logo ‡*a   Roberto Frigerio,‡a   Angelo Musicò,a   Giulia Lodigiani,a   Paola Gagni, ORCID logo a   Riccardo Vago,b   Marina Cretich*a  and  Alessandro Gori*a  

* Corresponding authors

a Istituto di Scienze e Tecnologie Chimiche “Giulio Natta” – National Research Council of Italy (SCITEC-CNR), 20131 Milan, Italy

b Urological Research Institute, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Università Vita-Salute San Raffaele, Milano, Italy

Abstract

In the present work, we report a proof-of-concept application of a composite Aga-Q3 hydrogel for the gentle confinement and analysis of extracellular vesicles (EVs) on microarray analytical platforms. Thanks to their peculiar functional properties, our 3D microdroplets are suitable to phenotype EVs with specific anti-surface antigen bioprobes, including antibodies and peptides.

Graphical abstract: Extracellular vesicle analysis in supramolecular 3D hydrogels: a proof-of-concept

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Article information

DOI
https://doi.org/10.1039/D3SD00313B
Article type
Communication
Submitted
22 Nov 2023
Accepted
07 Feb 2024
First published
19 Feb 2024
This article is Open Access
Creative Commons BY-NC license

Sens. Diagn., 2024,3, 395-399

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Extracellular vesicle analysis in supramolecular 3D hydrogels: a proof-of-concept

G. Bergamaschi, R. Frigerio, A. Musicò, G. Lodigiani, P. Gagni, R. Vago, M. Cretich and A. Gori, Sens. Diagn., 2024, 3, 395 DOI: 10.1039/D3SD00313B

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