Issue 36, 2024

Decellularized extracellular matrix-based bioengineered 3D breast cancer scaffolds for personalized therapy and drug screening

Abstract

Breast cancer (BC) is the second deadliest cancer after lung cancer. Similar to all cancers, it is also driven by a 3D microenvironment. The extracellular matrix (ECM) is an essential component of the 3D tumor micro-environment, wherein it functions as a scaffold for cells and provides metabolic support. BC is characterized by alterations in the ECM. Various studies have attempted to mimic BC-specific ECMs using artificial materials, such as Matrigel. Nevertheless, research has proven that naturally derived decellularized extracellular matrices (dECMs) are superior in providing the essential in vivo-like cues needed to mimic a cancer-like environment. Developing in vitro 3-D BC models is not straightforward and requires extensive analysis of the data established by researchers. For the benefit of researchers, in this review, we have tried to highlight all developmental studies that have been conducted by various scientists so far. The analysis of the conclusions drawn from these studies is also discussed. The advantages and drawbacks of the decellularization methods employed for generating BC scaffolds will be covered, and the review will shed light on how dECM scaffolds help develop a BC environment. The later stages of the article will also focus on immunogenicity issues arising from decellularization and the origin of the tissue. Finally, this review will also discuss the biofabrication of matrices, which is the core part of the bioengineering process.

Graphical abstract: Decellularized extracellular matrix-based bioengineered 3D breast cancer scaffolds for personalized therapy and drug screening

Article information

Article type
Review Article
Submitted
30 Mar 2024
Accepted
03 Aug 2024
First published
07 Aug 2024

J. Mater. Chem. B, 2024,12, 8843-8867

Decellularized extracellular matrix-based bioengineered 3D breast cancer scaffolds for personalized therapy and drug screening

T. Bhattacharya, M. Kumari, K. Kaur, S. Kaity, S. Arumugam, V. Ravichandiran and S. Roy, J. Mater. Chem. B, 2024, 12, 8843 DOI: 10.1039/D4TB00680A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements