Issue 38, 2024

Organelle-resolved imaging of formaldehyde reveals its spatiotemporal dynamics

Abstract

Understanding the spatiotemporal dynamics of formaldehyde (FA) is crucial for elucidating its pathophysiology. In this study, we designed a series of organelle-resolved probes to investigate FA dynamics. By incorporating various organelle anchors into a coumarin hydrazonate, we developed a series of probes with excellent organelle selectivity and FA specificity, enabling rapid and precise sensing of FA in an organelle-resolved way. Leveraging these probes, we captured the spatiotemporal dynamics of native FA in response to exogenous FA or oxidative stress challenges. In particular, we unveiled the distinct responses of various organelles to identical cellular stressors. Moreover, we observed the dynamic response within individual organelles when cells were exposed to stressors for varying durations. We envision these probes will serve as versatile tools for probing FA pathophysiology.

Graphical abstract: Organelle-resolved imaging of formaldehyde reveals its spatiotemporal dynamics

Supplementary files

Article information

Article type
Paper
Submitted
17 Jun 2024
Accepted
27 Aug 2024
First published
03 Sep 2024

J. Mater. Chem. B, 2024,12, 9592-9599

Organelle-resolved imaging of formaldehyde reveals its spatiotemporal dynamics

L. Zhou, Y. Pan, X. Li, T. Fan, X. Liang and X. Li, J. Mater. Chem. B, 2024, 12, 9592 DOI: 10.1039/D4TB01317D

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