Issue 35, 2024

Injectable and NIR-responsive CDN–POM hydrogels for combined non-inflammatory photo-immunotherapy

Abstract

Similar to clinically applied thermal ablation techniques, the cellular necrosis that occurs during photothermal tumor therapy (PTT) can induce inflammatory response, severely compromising the therapeutic efficacy and clinical translation of the PTT. Inspired by the remarkable ROS-scavenging activity and high photothermal efficiency of molybdenum-based polyoxometalate (POM) and the immunostimulatory effect of cyclic dinucleotides (CDNs), a NIR-responsive and injectable DNA-mediated hybrid hydrogel (CDN–POM) has been developed. The hydrogels have superior photothermal efficiency (43.41%) to POM, impressive anti-inflammatory capability and prolonged intratumoral CDN-releasing behavior, thus enabling synergistic anti-tumor therapeutic outcomes. Meanwhile, local treatment induced by CDN–POM hydrogels displays minimal side effects on normal tissue. Taking advantage of the high phototherapeutic effect, ROS-scavenging activity and sustained CDN release of CDN–POM hydrogels, a novel combined approach that integrates photothermal therapy and immunotherapy of breast tumor is successfully pioneered.

Graphical abstract: Injectable and NIR-responsive CDN–POM hydrogels for combined non-inflammatory photo-immunotherapy

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2024
Accepted
31 Jul 2024
First published
14 Aug 2024

J. Mater. Chem. B, 2024,12, 8616-8625

Injectable and NIR-responsive CDN–POM hydrogels for combined non-inflammatory photo-immunotherapy

H. Jiang, D. Liu, J. Wang, J. Li, X. Pang, H. Shan and K. Zhang, J. Mater. Chem. B, 2024, 12, 8616 DOI: 10.1039/D4TB01343C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements