A DNA conformational nanoswitch for amplification of both low-abundance protein imaging in living cells and photodynamic therapy

Mingzhu Fan; Wei Guo; Xinran Li; Huile Fan; Zhihui Luo; Jiayao Xu; Huakui Huang; Shulong Wang

doi:10.1039/D4AY02053G

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A DNA conformational nanoswitch for amplification of both low-abundance protein imaging in living cells and photodynamic therapy†

Mingzhu Fan,‡^a Wei Guo,‡^b Xinran Li,^a Huile Fan,^c Zhihui Luo,^a Jiayao Xu,

*^a Huakui Huang*^b and Shulong Wang*^a

Author affiliations

* Corresponding authors

^a Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, Yulin, China
E-mail: xujiayao_2011@163.com, shulonghs@163.com

^b Guangxi Medical University, Nanning, China
E-mail: huanghuakui2017@163.com

^c Guangxi Nanning Intellectual Property Protection Center, Nanning, China

Abstract

A method was developed for inducing a DNA conformational nanoswitch triggered by proteins, intended for fluorescence signal amplification imaging and photodynamic therapy targeting tumor cells.

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DOI: https://doi.org/10.1039/D4AY02053G
Article type: Paper
Submitted: 12 Nov 2024
Accepted: 09 Dec 2024
First published: 10 Dec 2024

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Anal. Methods, 2025,17, 708-713

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A DNA conformational nanoswitch for amplification of both low-abundance protein imaging in living cells and photodynamic therapy

M. Fan, W. Guo, X. Li, H. Fan, Z. Luo, J. Xu, H. Huang and S. Wang, Anal. Methods, 2025, 17, 708 DOI: 10.1039/D4AY02053G

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Analytical Methods

A DNA conformational nanoswitch for amplification of both low-abundance protein imaging in living cells and photodynamic therapy†

Abstract

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A DNA conformational nanoswitch for amplification of both low-abundance protein imaging in living cells and photodynamic therapy

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