A versatile approach for geometry-based self-assembly of DNA–protein hybrid nanostructures using histone–DNA interactions

Abstract

We report an enhanced versatility in constructing DNA–protein hybrid nanostructures using histone–DNA complexes (HDs). By leveraging HDs, we demonstrate precise and scalable assembly of DNA origami tiles and a 2D triangular nanostructure. Our results extend the potential applications of DNA nanotechnology from the nanoscale to the microscale without the need for complex pre-designs.