Localized high probe density greatly improves the signaling stability of supramolecular electrochemical aptamer-based (Supra-EAB) sensors

Abstract

DNA aptamers have emerged as a promising class of probes for the development of biosensors. However, the only viable strategy thus far for adjustment of probe densities is tuning DNA concentrations. Herein, we constructed a class of Supra-EAB sensors to introduce localized high probe densities and achieved significantly improved stability against enzymes.